The bottom line
Most people with clinical depression have tried medications. SSRIs are a multi-billion dollar business, and there are thousands of papers to wade through to estimate how effective they are for different people.
There are other medications that may improve depression outside of SSRIs though. And there are also non-pharmaceutical approaches that are done at hospitals and doctor’s offices. Basically, medical treatment for depression encompasses a massive number of different treatment strategies, and it’s going to take you some time and effort to understand the research for the major ones.